HCID 22936266, compound → HCID 22936256, compound

HRID 1433601Notes

Reaction equation

HRID 1433601 reaction equation
F[C:2](F)(F)[C:3](O)=[O:4].[NH2:8][CH2:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:19]=1[O:20][CH3:21])[N:16]=[CH:15][CH:14]=[C:13]2[O:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30]([NH:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:31])=[CH:25][CH:24]=1>N1C=CC=CC=1.C(OC(=O)C)(=O)C>[C:3]([NH:8][CH2:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:19]=1[O:20][CH3:21])[N:16]=[CH:15][CH:14]=[C:13]2[O:22][C:23]1[CH:24]=[CH:25][C:26]([NH:29][C:30]([NH:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[O:31])=[CH:27][CH:28]=1)(=[O:4])[CH3:2]

Participants

4

Reactant 1

HCID 22936266HCID 22936266, compound

Product 1

HCID 22936256HCID 22936256, compoundYield 37.6%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 7918Acetic AnhydrideSolvent

Procedure

After dissolving N-[4-(6-aminomethyl-7-methoxy-quinolin-4-yloxy)phenyl]-N′-phenylurea trifluoroacetate (40 mg) in pyridine (1.0 ml) and acetic anhydride (1.0 ml), the solution was stirred overnight at room temperature. The reaction solution was concentrated under reduced pressure and the obtained crude product was crystallized with ethyl acetate to obtain the title compound (13 mg).

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe obtained crude product
  3. customwas crystallized with ethyl acetate

Sources & evidence

ORD record
ord-a5e119c14b874ebaaf87110b217e39c1
Source dataset
uspto-grants-2009_11
Patent number
US07612092B2

Reaction notes

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