反应详情

After adding thionyl chloride (8.0 ml) and dimethylformamide (0.08 ml) to 4-oxo-4,7-dihydro-furo[2.3-b]pyridine-2-carboxylic acid methyl ester (2.0 g), the mixture was heated to reflux for 1 hour. After cooling, the mixture was concentrated under reduced pressure and the precipitated crystals were filtered out and washed with tetrahydrofuran and ethyl acetate to obtain the title compound (2.1 g).

1. temperaturethe mixture was heated
2. temperatureto reflux for 1 hour
3. temperatureAfter cooling
4. concentrationthe mixture was concentrated under reduced pressure
5. filtrationthe precipitated crystals were filtered out
6. washwashed with tetrahydrofuran and ethyl acetate