Toluene → HCID 58931434, compound

HRID 1433630Notes

Reaction equation

HRID 1433630 reaction equation
C1(C)C=CC=CC=1.[F:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[O:17])=[CH:11][CH:10]=1.[C:18]1([C:24]2[O:40][C:27]3[N:28]=[CH:29][N:30]=[C:31]([O:32][C:33]4[CH:38]=[CH:37][C:36]([NH2:39])=[CH:35][CH:34]=4)[C:26]=3[CH:25]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(#N)C>[F:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH:39][C:36]2[CH:35]=[CH:34][C:33]([O:32][C:31]3[C:26]4[CH:25]=[C:24]([C:18]5[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=5)[O:40][C:27]=4[N:28]=[CH:29][N:30]=3)=[CH:38][CH:37]=2)=[O:17])=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 709554-Fluorophenyl isocyanateHCID 58931477HCID 58931477, compound

Product 1

HCID 58931434HCID 58931434, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

After adding toluene (1 ml), acetonitrile (0.5 ml) and 4-fluorophenyl isocyanate (0.03 ml) to 4-(6-phenyl-furo[2.3-d]pyrimidin-4-yloxy)phenylamine (40 mg), the mixture was heated to reflux for 30 minutes. After cooling, the precipitated crystals were filtered out and washed with toluene to obtain the title compound (42 mg) as light yellow crystals.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 30 minutes
  3. temperatureAfter cooling
  4. filtrationthe precipitated crystals were filtered out
  5. washwashed with toluene

Sources & evidence

ORD record
ord-2bc84d8656a34056ac09ec9668578625
Source dataset
uspto-grants-2009_11
Patent number
US07612092B2

Reaction notes

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