Methylamine → HCID 22936664, compound

HRID 1433728Notes

Reaction equation

HRID 1433728 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:30][CH3:31])=[C:24]([C:27](=[O:29])[NH2:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[C:32]([F:35])([F:34])[F:33])C=CC=CC=1.[CH3:37][NH2:38]>>[C:27]([C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:30][CH3:31])[N:20]=[CH:19][CH:18]=[C:17]2[O:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:8]([NH:38][CH3:37])=[O:7])=[C:11]([C:32]([F:34])([F:33])[F:35])[CH:12]=1)(=[O:29])[NH2:28]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 67202368HCID 67202368, compound

Product 1

HCID 22936664HCID 22936664, compound

Procedure

After adding [4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-trifluoromethylphenyl]carbamic acid phenyl ester (25 mg) to methylamine 2N tetrahydrofuran solution (1.00 ml), the mixture was stirred for 10 minutes. The precipitated crystals were filtered out and washed with tetrahydrofuran to obtain the title compound (10 mg).

Workup

  1. filtrationThe precipitated crystals were filtered out
  2. washwashed with tetrahydrofuran

Sources & evidence

ORD record
ord-7b4943dbf30649b98b6d1b5aee30a836
Source dataset
uspto-grants-2009_11
Patent number
US07612092B2

Reaction notes

Loading…