反应详情

Prepared by the same method as described in example 1 except that (i) 4-iodoaniline was used in place of 4-bromoaniline in step 2 and (ii) (R)-tert-butoxycarbonylamino [4-(2-morpholin-4-yl-2-oxo-ethoxy)-phenyl]-acetic acid was used in place of (R)-tert-butyloxycarbonylamino-4-methoxyphenylglycine. (R)-tert-Butoxycarbonylamino[4-(2-morpholin-4-yl-2-oxo-ethoxy)-phenyl]-acetic acid was prepared by a method similar to that used for the preparation of (R)-tert-butyloxycarbonylamino-4-methoxyphenylglycine in example 1 except that 2-chloro-1-morpholin-4-yl-ethanone was used in place of iodomethane.

1. customPrepared by the same method