Morpholine, 4-(chloroacetyl)- → (R)-tert-Butoxycarbonylamino[4-(2-morpholin-4-yl-2-oxo-ethoxy)-phenyl]-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Morpholine, 4-(chloroacetyl)-	HCID 74040	—
Reactant	L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-	HCID 77857	—
Reactant	(R)-tert-Butoxycarbonylamino-[4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-acetic acid	HCID 67001404	—
Product	(R)-tert-Butoxycarbonylamino[4-(2-morpholin-4-yl-2-oxo-ethoxy)-phenyl]-acetic acid	HCID 69008770	—

Reaction Steps

Prepared by the same method as described in example 1 except that (i) 4-iodoaniline was used in place of 4-bromoaniline in step 2 and (ii) (R)-tert-butoxycarbonylamino [4-(2-morpholin-4-yl-2-oxo-ethoxy)-phenyl]-acetic acid was used in place of (R)-tert-butyloxycarbonylamino-4-methoxyphenylglycine. (R)-tert-Butoxycarbonylamino[4-(2-morpholin-4-yl-2-oxo-ethoxy)-phenyl]-acetic acid was prepared by a method similar to that used for the preparation of (R)-tert-butyloxycarbonylamino-4-methoxyphenylglycine in example 1 except that 2-chloro-1-morpholin-4-yl-ethanone was used in place of iodomethane.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612212B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-3529cc904fa54472b59f6736a5671fd9
Source note	uspto-grants-2009_11