(2S,3S)-2-((tert-Butoxycarbonyl)amino)-3-phenylbutanoic acid → (R)-tert-Butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	(2S,3S)-2-((tert-Butoxycarbonyl)amino)-3-phenylbutanoic acid	HCID 7021178	—
Reactant	(2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid	HCID 16213170	—
Reactant	(R)-tert-Butoxycarbonylamino-[4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-acetic acid	HCID 67001404	—
Reactant	(2S,3S)-2-{(R)-2-amino-2-[4-((R)-2,3-dihydroxy-propoxy)-phenyl]-acetylamino}-N-(2-chloro-4-iodo-phenyl)-3-phenyl-butyramide	HCID 69006543	—
Product	(R)-tert-Butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid	HCID 66815175	—

Reaction Steps

Prepared by the same method as described in example 3 except that (i) 2-chloro-4-iodoaniline was used in place of 4-bromo-2-chloroaniline in step 1, (ii) (2S,3S)-2-tert-butoxycarbonylamino-3-methyl-pentanoic acid was used in place (2S,3S)-2-tert-butoxycarbonylamino-3-phenyl-butyric acid in step 1, and (iii) (R)-tert-butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 2. (R)-tert-Butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid was prepared as described in example 80.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612212B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-59e7e60a94fd4a7eba066f2449484566
Source note	uspto-grants-2009_11