4-Fluorobenzonitrile → 4-(1-Methylpiperidin-4-yloxy)benzaldehyde

HRID 1433810Notes

Reaction equation

HRID 1433810 reaction equation
[OH:1]C1CCN(C)CC1.FC1C=CC(C#N)=CC=1.[CH3:18][N:19]1[CH2:24][CH2:23][CH:22]([O:25][C:26]2[CH:33]=[CH:32][C:29]([C:30]#N)=[CH:28][CH:27]=2)[CH2:21][CH2:20]1>>[CH3:18][N:19]1[CH2:24][CH2:23][CH:22]([O:25][C:26]2[CH:33]=[CH:32][C:29]([CH:30]=[O:1])=[CH:28][CH:27]=2)[CH2:21][CH2:20]1

Participants

4

Reactant 3

HCID 145174-FluorobenzonitrileHCID 660484-Piperidinol, 1-methyl-HCID 114585954-(1-Methylpiperidin-4-yloxy)benzonitrile

Product 1

HCID 234332974-(1-Methylpiperidin-4-yloxy)benzaldehyde

Procedure

Synthesized from 4-hydroxy-1-methylpiperidine and 4-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 4-(1-methylpiperidin-4-yloxy)benzonitrile (500 mg) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (350 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Sources & evidence

ORD record
ord-7bc6818be9e14b41958f740c066828c3
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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