4-Piperidinol, 1-methyl- → HCID 23087228, compound

HRID 1433817Notes

Reaction equation

HRID 1433817 reaction equation
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

Participants

4

Reactant 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

Product 1

HCID 23087228HCID 23087228, compound

Procedure

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Sources & evidence

ORD record
ord-230cd4b996c84e2fbb2af1b06b21455e
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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