1-Bromo-2-nitrobenzene → 2-(6-Methoxy-3,3-dimethyl-3,4-dihydronaphthalen-2-yl)phenylamine

HRID 1433902Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1433902
BrC1C(C)(C)CC2C(C=1)=CC=C(OC)C=2.BrC1C=CC=CC=1[N+]([O-])=O.[CH3:26][O:27][C:28]1[CH:37]=[C:36]2[C:31]([CH:32]=[C:33]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=3[N+:46]([O-])=O)[C:34]([CH3:39])([CH3:38])[CH2:35]2)=[CH:30][CH:29]=1>>[CH3:26][O:27][C:28]1[CH:37]=[C:36]2[C:31](=[CH:30][CH:29]=1)[CH:32]=[C:33]([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1[NH2:46])[C:34]([CH3:39])([CH3:38])[CH2:35]2

Komponenten

4

Edukt 3

HCID 113411-Bromo-2-nitrobenzeneHCID 230875527-Methoxy-2,2-dimethyl-3-(2-nitrophenyl)-1,2-dihydronaphthaleneHCID 230875703-Bromo-7-methoxy-2,2-dimethyl-1,2-dihydronaphthalene

Produkt 1

HCID 230874972-(6-Methoxy-3,3-dimethyl-3,4-dihydronaphthalen-2-yl)phenylamineAusbeute 53,5 %

Versuchsvorschrift

Synthesized from 3-bromo-7-methoxy-2,2-dimethyl-1,2-dihydronaphthalene and 1-bromo-2-nitrobenzene according to an analogous synthetic method to Preparation Example 107 described below, 7-methoxy-2,2-dimethyl-3-(2-nitrophenyl)-1,2-dihydronaphthalene (1.4 g) was used according to an analogous synthetic method to Example 57 to provide the title compound (676 mg).

Quellen und Nachweise

ORD-Eintrag
ord-9d3451f145e6432fa6898fbbb73474ec
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612114B2

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