Dichloromethane → HCID 23087516, compound

HRID 1434129Notes

Reaction equation

HRID 1434129 reaction equation
C([O:5][C:6](=O)[N:7]([CH2:9][CH2:10][O:11][CH2:12][CH3:13])[CH3:8])(C)(C)C.FC(F)(F)C(O)=O.[Cl:22][CH2:23]Cl>>[Cl:22][CH2:23][C:6]([N:7]([CH2:9][CH2:10][O:11][CH2:12][CH3:13])[CH3:8])=[O:5]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57934553HCID 57934553, compound

Product 1

HCID 23087516HCID 23087516, compound

Procedure

To a solution of tert-butyl(2-ethoxyethyl)methylcarbamate (1.2 g) in dichloromethane (6 ml) was added trifluoroacetic acid (6 ml) on an ice bath. The solution was stirred for 30 minutes while warming to room temperature, then the solvent was evaporated in vacuo. Synthesized from the resulting (2-ethoxyethyl)methylamine trifluoroacetate (crude product) (2.3 g) according to an analogous synthetic method to Preparation Example 119, the title compound (799 mg) was obtained.

Workup

  1. customthe solvent was evaporated in vacuo
  2. customSynthesized from the resulting (2-ethoxyethyl)methylamine trifluoroacetate (crude product) (2.3 g)
  3. customaccording to an analogous synthetic method to Preparation Example 119

Sources & evidence

ORD record
ord-78cf3caa451f48f98973d9d431c76c92
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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