Pyrrolidine → HCID 57934257, compound

HRID 1434403Notes

Reaction equation

HRID 1434403 reaction equation
C(CC1C=CC(C[CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=2[C@@H:23]2[CH2:32][CH2:31][C:30]3[CH:29]=[C:28]([O:33]C(=O)C(C)(C)C)[CH:27]=[CH:26][C:25]=3[CH2:24]2)=CC=1)(O)=O.[NH:42]1[CH2:46][CH2:45][CH2:44][CH2:43]1>>[CH2:11]([N:12]([CH2:29][C:30]1[CH:31]=[CH:32][C:23]([CH2:14][CH2:13][N:42]2[CH2:46][CH2:45][CH2:44][CH2:43]2)=[CH:24][CH:25]=1)[C:13]1[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=1[C@@H:23]1[CH2:32][CH2:31][C:30]2[CH:29]=[C:28]([OH:33])[CH:27]=[CH:26][C:25]=2[CH2:24]1)[CH3:10]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 86605262HCID 86605262, compound

Product 1

HCID 57934257HCID 57934257, compoundYield 43.5%

Procedure

Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and pyrrolidine (12 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (3.8 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-60e4075a0cea4c09a5f2ed8009388446
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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