Resorcinol → Methanone, (2-hydroxy-4-methoxyphenyl)(4-methoxyphenyl)-

HRID 1434426Notes

Reaction equation

[C:1]1(C=CC=C(O)C=1)O.COC1C=CC(C(Cl)=O)=CC=1.[OH:20][C:21]1[CH:26]=[C:25]([OH:27])[CH:24]=[CH:23][C:22]=1[C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)=[O:29].CI>>[OH:20][C:21]1[CH:26]=[C:25]([O:27][CH3:1])[CH:24]=[CH:23][C:22]=1[C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)=[O:29]

Participants

Reactant 4

HCID 5054Resorcinol

HCID 6328Methyl iodide

HCID 7477p-Anisoyl chloride

HCID 350227(2,4-Dihydroxyphenyl)(4-methoxyphenyl)methanone

Product 1

HCID 96154Methanone, (2-hydroxy-4-methoxyphenyl)(4-methoxyphenyl)-

Procedure

Synthesized from resorcinol and 4-methoxybenzoyl chloride according to an analogous synthetic method to Preparation Example 66, (2,4-dihydroxyphenyl)(4-methoxyphenyl)methanone (9.7 g) and methyl iodide (13.1 g) were used according to an analogous synthetic method to Example 383 to provide the title compound (7.0 g).

Sources & evidence

ORD record: ord-b49493b0c8c0436ca91307666c2eab39
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07612114B2

Reaction notes

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