反应详情

A mixture of pivalic acid 6-(2-amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (110 mg), bromoethyl acetate (400 mg), sodium acetate (200 mg) and ethanol (2 ml) was refluxed overnight. A saturated aqueous solution of sodium bicarbonate was added, and the solution was extracted with ethyl acetate. The solution was washed with brine, dried over magnesium sulfate, and then the solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (hexane-ethyl acetate system) to provide the title compound (83 mg).

1. temperaturewas refluxed overnight
2. extractionthe solution was extracted with ethyl acetate
3. washThe solution was washed with brine
4. dry with materialdried over magnesium sulfate
5. customthe solvent was evaporated in vacuo
6. customThe residue was purified by silica gel column chromatography (hexane-ethyl acetate system)