HCID 86605953, compound → HCID 69073210, compound

HRID 1434518Notes

Reaction equation

HRID 1434518 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][C:9]2=[O:14])[CH:5]=[CH:4][C:3]=1[N:15]1[C:19](=[O:20])[CH2:18][C@@H:17]([NH:21]C(=O)OCC2C=CC=CC=2)[CH2:16]1.[H][H]>CO.[Pd]>[NH2:21][C@H:17]1[CH2:16][N:15]([C:3]2[CH:4]=[CH:5][C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][C:9]3=[O:14])=[CH:7][C:2]=2[F:1])[C:19](=[O:20])[CH2:18]1

Participants

5

Reactant 2

HCID 86605953HCID 86605953, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69073210HCID 69073210, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

260 mg (0.6 mmol) benzyl (R)-{1-[2-fluoro-4-(3-oxo-morpholin-4-yl)-phenyl]-5-oxo-pyrrolidin-3-yl}-carbamate are dissolved in 10 ml of methanol, combined with 180 mg palladium on charcoal and hydrogenated for 3.75 hours in a Parr apparatus at 3 bar hydrogen pressure at ambient temperature.

Sources & evidence

ORD record
ord-82417a3014224818bae741bff36b9200
Source dataset
uspto-grants-2009_11
Patent number
US07615549B2

Reaction notes

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