Itaconic acid → HCID 69070418, compound

HRID 1434521Notes

Reaction equation

HRID 1434521 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]2=[O:14])=[CH:4][C:3]=1[F:15].[C:16]([OH:24])(=[O:23])[C:17]([CH2:19][C:20](O)=[O:21])=[CH2:18]>>[F:15][C:3]1[CH:4]=[C:5]([N:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]2=[O:14])[CH:6]=[CH:7][C:2]=1[N:1]1[C:20](=[O:21])[CH2:19][CH:17]([C:16]([OH:24])=[O:23])[CH2:18]1

Participants

3

Reactant 2

HCID 811Itaconic acidHCID 221815481-(4-Amino-3-fluorophenyl)pyridin-2-one

Product 1

HCID 69070418HCID 69070418, compound

Procedure

Prepared analogously to Example 1d from 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one by melting with itaconic acid. The crude product is purified by reversed-phase chromatography.

Workup

  1. customThe crude product is purified by reversed-phase chromatography

Sources & evidence

ORD record
ord-dcbb893222a54d218c0853e7b92448c1
Source dataset
uspto-grants-2009_11
Patent number
US07615549B2

Reaction notes

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