tert-Butanol → HCID 86605955, compound

HRID 1434522Notes

Reaction equation

HRID 1434522 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]2=[O:14])[CH:5]=[CH:4][C:3]=1[N:15]1[C:19](=[O:20])[CH2:18][CH:17](C(O)=O)[CH2:16]1.C1C=CC(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:31])=CC=1.[C:41]([OH:45])([CH3:44])([CH3:43])[CH3:42].C([N:48]([CH2:51]C)CC)C>>[F:1][C:2]1[CH:7]=[C:6]([N:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]2=[O:14])[CH:5]=[CH:4][C:3]=1[N:15]1[C:19](=[O:20])[CH2:18][CH:17]([NH:48][C:51](=[O:31])[O:45][C:41]([CH3:44])([CH3:43])[CH3:42])[CH2:16]1

Participants

5

Reactant 4

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 69070418HCID 69070418, compound

Product 1

HCID 86605955HCID 86605955, compound

Procedure

Prepared analogously to Example 1e from 1-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid by carboxylic acid breakdown by means of DPPA, tert.-butanol and triethylamine.

Sources & evidence

ORD record
ord-f2922a1e080b40818ffd135c2b5b2efd
Source dataset
uspto-grants-2009_11
Patent number
US07615549B2

Reaction notes

Loading…