HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl ((3R,4R)-4-methyl-5-oxotetrahydrofuran-3-yl)carbamate → benzyl {(1R,2R)-1-hydroxymethyl-2-[3-methyl-4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-propyl}-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl ((3R,4R)-4-methyl-5-oxotetrahydrofuran-3-yl)carbamate | HCID 13108321 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | 4-(4-Amino-2-methylphenyl)morpholin-3-one | HCID 23105288 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | benzyl {(1R,2R)-1-hydroxymethyl-2-[3-methyl-4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-propyl}-carbamate | HCID 86605956 | — |
Reaction Steps
Prepared analogously to Example 2b from 4-(4-amino-2-methyl-phenyl)-morpholin-3-one and benzyl [(3R,4R)-4-methyl-5-oxo-tetrahydrofuran-3-yl]-carbamate with trimethylaluminium in THF and subsequent purification by reversed-phase chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615549B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-6ac37ebc32fa4e0ea1ad7fe0606d30f4 |
| Source note | uspto-grants-2009_11 |