HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → benzyl {(3R,4R)-4-methyl-1-[3-methyl-4-(3-oxo-morpholin-4-yl)-phenyl]-5-oxo-pyrrolidin-3-yl}-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | benzyl {(1R,2R)-1-hydroxymethyl-2-[3-methyl-4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-propyl}-carbamate | HCID 86605956 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | benzyl {(3R,4R)-4-methyl-1-[3-methyl-4-(3-oxo-morpholin-4-yl)-phenyl]-5-oxo-pyrrolidin-3-yl}-carbamate | HCID 86605957 | — |
Reaction Steps
Prepared analogously to Example 2c from benzyl {(1R,2R)-1-hydroxymethyl-2-[3-methyl-4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-propyl}-carbamate with di-tert.-butyl azodicarboxylate and tributylphosphine in THF and subsequent purification by reversed-phase chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615549B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-0a8b5168102c47c7adf0da2c5e930809 |
| Source note | uspto-grants-2009_11 |