反应详情

10.2 g (64.4 mmol) of 2-methylphenylhydrazine hydrochloride are suspended with 7.8 g (64.4 mmol) of ethoxymethylenemalononitrile in 100 ml of methanol, and 26.9 ml (193.3 mmol) of triethylamine are added. The reaction mixture is heated to reflux overnight, during which a clear solution forms. The solution is subsequently distilled off under reduced pressure, and the crude product is purified by column chromatography (silica gel, mobile phase dichloromethane). 10.8 g (85% of theory) of the desired product are obtained.

1. additionare added
2. temperatureThe reaction mixture is heated
3. temperatureto reflux overnight, during which a clear solution forms
4. distillationThe solution is subsequently distilled off under reduced pressure
5. customthe crude product is purified by column chromatography (silica gel, mobile phase dichloromethane)