4-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester → 1-[4-(3-Piperidin-1-ylpropoxy)phenyl]piperazine

HRID 1434570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1434570
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[N:24]1([CH2:23][CH2:22][CH2:21][O:20][C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:15][CH:16]=2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Komponenten

3

Edukt 1

HCID 588178414-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 99240131-[4-(3-Piperidin-1-ylpropoxy)phenyl]piperazineAusbeute 101,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 4-[4-(3-piperidin-1-yl-propoxy)phenyl]-piperazine-1-carboxylic acid tert-butyl ester (D10) (1.0 g; 2.48 mM) in trifluoroacetic acid (5 ml) was stirred at room temperature for 60 minutes. The resulting mixture was purified on an SCX ion exchange cartridge to afford the title compound as a colourless crystalline solid (0.76 g)

Aufarbeitung

  1. customThe resulting mixture was purified on an SCX ion exchange cartridge

Quellen und Nachweise

ORD-Eintrag
ord-6d15d0bdec934c0d8b651e670b803168
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07615550B2

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