tert-Butyl 4-(3-hydroxyphenyl)piperazine-1-carboxylate → 4-[3-(3-Chloro-propoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

HRID 1434571Notes

Reaction equation

HRID 1434571 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(N1CCN(C2C=CC(O[CH2:41][CH2:42][CH2:43][Cl:44])=CC=2)CC1)=O)(C)(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:41][CH2:42][CH2:43][Cl:44])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 18669061tert-Butyl 4-(3-hydroxyphenyl)piperazine-1-carboxylateHCID 588178434-[4-(3-Chloro-propoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 686998124-[3-(3-Chloro-propoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Procedure

Prepared from 4-(3-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (D12) using the same method described in Description 9 (D9).

Sources & evidence

ORD record
ord-7c697bfc38044029832253a8cdee4d57
Source dataset
uspto-grants-2009_11
Patent number
US07615550B2

Reaction notes

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