1-[4-(3-Piperidin-1-yl-propoxy)-benzyl]-[1,4]diazepane → Phenyl[4-({4-[(piperidin-4-yl)oxy]phenyl}methyl)piperazin-1-yl]methanone

HRID 1434580Notes

Reaction equation

HRID 1434580 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:22]3[CH2:27][CH2:26][N:25]([C:28]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[O:29])[CH2:24][CH2:23]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.N1(CCCOC2C=CC(CN3CCCNCC3)=CC=2)CCCCC1>>[C:30]1([C:28]([N:25]2[CH2:24][CH2:23][N:22]([CH2:21][C:18]3[CH:19]=[CH:20][C:15]([O:14][CH:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)=[CH:16][CH:17]=3)[CH2:27][CH2:26]2)=[O:29])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 596405921-[4-(3-Piperidin-1-yl-propoxy)-benzyl]-[1,4]diazepaneHCID 687021234-{4-[4-(1-Phenyl-methanoyl)-piperazin-1-ylmethyl]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 57935703Phenyl[4-({4-[(piperidin-4-yl)oxy]phenyl}methyl)piperazin-1-yl]methanone

Procedure

The title compound (E32) was prepared from 4-{4-[4-(1-phenyl-methanoyl)-piperazin-1-ylmethyl]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester (D7) using the method described in Description 4 (D4). MS(ES+) m/e 380 [M+H]+.

Sources & evidence

ORD record
ord-b147f8fac206488cbd72ad7fdf553214
Source dataset
uspto-grants-2009_11
Patent number
US07615550B2

Reaction notes

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