HRID1434594

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17981338

未命名化合物

HCID57935959

未命名化合物

结构：CCOC(=O)c1csc(C2CCN(CCC(c3ccccc3)C3CCN(S(C)(=O)=O)CC3)CC2)n1

HCID68709951

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)N1CCC(C(CCN2CCC(c3nc(C(=O)O)cs3)CC2)c2ccccc2)CC1

HCID57935991

未命名化合物

PROCEDURE

实验过程

The ethyl 2-(1-{3-[1-(methylsulfonyl)piperidin-4-yl]-3-phenylpropyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate used as starting material was prepared by reductive amination of 3-[1-(methylsulfonyl)piperidin-4-yl]-3-phenylpropanal (prepared following Method I using 4-benzoyl-N-methanesulphonylpiperidine as starting material) with ethyl 2-piperidin-4-yl-1,3-thiazole-4-carboxylate (Method K) as the amine component.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-15763013d78642f9bef42f96c2ee04ad
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07615555B2
来源说明: uspto-grants-2009_11

反应 SMILES

[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][CH:8]([CH:11]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20]3[S:21][CH:22]=[C:23]([C:25]([O:27]CC)=[O:26])[N:24]=3)[CH2:16][CH2:15]2)[CH2:7][CH2:6]1)(=[O:4])=[O:3].CS(N1CCC(C(C2C=CC=CC=2)CC=O)CC1)(=O)=O.N1CCC(C2SC=C(C(OCC)=O)N=2)CC1>>[CH3:1][S:2]([N:5]1[CH2:6][CH2:7][CH:8]([CH:11]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([C:20]3[S:21][CH:22]=[C:23]([C:25]([OH:27])=[O:26])[N:24]=3)[CH2:18][CH2:19]2)[CH2:9][CH2:10]1)(=[O:4])=[O:3]