HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1-Methanesulphonylpiperidin-4-yl)-3-phenylpropionaldehyde → 2-(1-{3-[1-(Methylsulfonyl)piperidin-4-yl]-3-phenylpropyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1-Methanesulphonylpiperidin-4-yl)-3-phenylpropionaldehyde | HCID 17981338 | — |
| Reactant | 2-Piperidine-4-yl-thiazole-4-carboxylic acid ethyl ester | HCID 57935959 | — |
| Reactant | Ethyl 2-(1-{3-[1-(methylsulfonyl)piperidin-4-yl]-3-phenylpropyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate | HCID 68709951 | — |
| Product | 2-(1-{3-[1-(Methylsulfonyl)piperidin-4-yl]-3-phenylpropyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid | HCID 57935991 | — |
Reaction Steps
The ethyl 2-(1-{3-[1-(methylsulfonyl)piperidin-4-yl]-3-phenylpropyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate used as starting material was prepared by reductive amination of 3-[1-(methylsulfonyl)piperidin-4-yl]-3-phenylpropanal (prepared following Method I using 4-benzoyl-N-methanesulphonylpiperidine as starting material) with ethyl 2-piperidin-4-yl-1,3-thiazole-4-carboxylate (Method K) as the amine component.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615555B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-15763013d78642f9bef42f96c2ee04ad |
| Source note | uspto-grants-2009_11 |