Hydrochloric Acid → 3-piperidin-4-yl-3H-imidazo[4,5-c]pyridine

HRID 1434609Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1434609
[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]([CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH:2]=1.Cl.C(OCC)C>O1CCOCC1.O1C=COC=C1>[NH:13]1[CH2:12][CH2:11][CH:10]([N:3]2[C:4]3[CH:5]=[N:6][CH:7]=[CH:8][C:9]=3[N:1]=[CH:2]2)[CH2:15][CH2:14]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 57935983HCID 57935983, Verbindung

Produkt 1

HCID 579359853-piperidin-4-yl-3H-imidazo[4,5-c]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 312751,4-DioxaneLösungsmittelHCID 789681,4-DioxinLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 4-(3H-imidazo[4,5-c]pyridine-3-yl)piperidine-1-carboxylate (1.12 g) in 1,4 dioxan (10 ml) was added 4M hydrochloric acid in dioxin (10 ml) and the resulting mixture was stirred for 3 hours. Diethyl ether (30 ml) was added and the mixture was filtered and washed with diethyl ether (50 ml) to give the title compound which was used without further purification. Yield 1.1 g. NMR (d6 DMSO) 2.35 (m, 2H), 2.5 (m, 2H), 3.1 (m, 2H), 3.5 (m, 2H), 5.05 (m, 1H), 8.3 (d, 1H), 8.65 (d, 1H), 9.3 (bd, 2H), 9.9 (s, 1H).

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. washwashed with diethyl ether (50 ml)

Quellen und Nachweise

ORD-Eintrag
ord-debdfcd163ce41d1a148966e890ba131
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07615555B2

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