HCID 57936024, compound → HCID 52988033, compound

Participants

Reaction Steps

A solution of 1-benzyl-4-[3-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl]piperidine (2.97 g) in ethanol (45 ml) was hydrogenated under a hydrogen filled balloon using 20% palladium hydroxide on charcoal as catalyst. The mixture was filtered through celite and evaporated to dryness to give the title compound, yield 2.14 g, LC-MS M+H 235, NMR (CDCl3); 1.90 (2H, d), 2.16 (2H, m), 2.42 (1H, br N—H), 2.66 (3H, s), 2.78 (2H, t), 3.32 (1H, d), 4.26 (1H, m).

Provenance & Evidence