HCID 57936024, compound → HCID 52988033, compound

HRID 1434610Notes

Reaction equation

HRID 1434610 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]([C:19]([F:22])([F:21])[F:20])=[N:17][N:16]=[C:15]2[CH3:23])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[CH3:23][C:15]1[N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:18]([C:19]([F:22])([F:20])[F:21])=[N:17][N:16]=1

Participants

4

Reactant 1

HCID 57936024HCID 57936024, compound

Product 1

HCID 52988033HCID 52988033, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

A solution of 1-benzyl-4-[3-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl]piperidine (2.97 g) in ethanol (45 ml) was hydrogenated under a hydrogen filled balloon using 20% palladium hydroxide on charcoal as catalyst. The mixture was filtered through celite and evaporated to dryness to give the title compound, yield 2.14 g, LC-MS M+H 235, NMR (CDCl3); 1.90 (2H, d), 2.16 (2H, m), 2.42 (1H, br N—H), 2.66 (3H, s), 2.78 (2H, t), 3.32 (1H, d), 4.26 (1H, m).

Workup

  1. filtrationThe mixture was filtered through celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-0f6c1b4555cf4c7f9dd4369dfce36750
Source dataset
uspto-grants-2009_11
Patent number
US07615555B2

Reaction notes

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