Benzyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate → 1-(Piperidin-4-yl)imidazolidin-2-one

HRID 1434612Notes

Reaction equation

HRID 1434612 reaction equation
[O:1]=[C:2]1[NH:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][N:10](C(OCC2C=CC=CC=2)=O)[CH2:9][CH2:8]1>C(O)C.[Pd]>[NH:10]1[CH2:9][CH2:8][CH:7]([N:3]2[CH2:4][CH2:5][NH:6][C:2]2=[O:1])[CH2:12][CH2:11]1

Participants

4

Reactant 1

HCID 23463818Benzyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

Product 1

HCID 130317571-(Piperidin-4-yl)imidazolidin-2-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of benzyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate (3.2 g) in ethanol (200 ml) was hydrogenated under a hydrogen filled balloon with 20% palladium on charcoal as catalyst. The catalyst was filtered and the filtrate evaporated to dryness to give the title compound as a white solid, yield 1.6 g.

Workup

  1. filtrationThe catalyst was filtered
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-26da20d065b84c89b7c4bff88de12523
Source dataset
uspto-grants-2009_11
Patent number
US07615555B2

Reaction notes

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