HCID 57935981, compound → HCID 57935960, compound

HRID 1434613Notes

Reaction equation

HRID 1434613 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]=[CH:17][N:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][CH:21]=3)[C:15]2=[O:30])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:29][S:26]([C:23]1[CH:22]=[CH:21][C:20]([CH2:19][N:16]2[CH2:17][CH2:18][N:14]([CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[C:15]2=[O:30])=[CH:25][CH:24]=1)(=[O:28])=[O:27]

Participants

4

Reactant 1

HCID 57935981HCID 57935981, compound

Product 1

HCID 57935960HCID 57935960, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1-(1-benzylpiperidin-4-yl)-3-[4-(methylsulphonyl)benzyl]-1,3-dihydro-2H-imidazol-2-one (1.2 g) in ethanol was hydrogenated under a hydrogen filled balloon using 20% palladium on charcoal as catalyst. The catalyst was filtered and the filtrate evaporated to dryness to give the title compound, yield 0.6 g, NMR CDCl3 1.6-2 (m, 5H) 2.8 (m, 1H) 3.05 (s, 3H) 3.2-4.5 (m, 7H) 4.45 (s, 2H) 7.5 (d, 2H) 7.9 (d, 2H).

Workup

  1. filtrationThe catalyst was filtered
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-73798d6ad9c042ecb033dbd0a248f64a
Source dataset
uspto-grants-2009_11
Patent number
US07615555B2

Reaction notes

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