HCID 24738061, compound → HCID 69065309, compound

HRID 1434631Notes

Reaction equation

HRID 1434631 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([C@H:16]3[CH2:20][CH2:19][CH2:18][C@@H:17]3[NH:21]C(=O)OC(C)(C)C)=[O:15])[CH2:10][C:9]2([CH3:30])[CH3:29])=[CH:4][CH:3]=1>Cl.O1CCOCC1>[ClH:1].[NH2:21][C@H:17]1[CH2:18][CH2:19][CH2:20][C@H:16]1[C:14]([N:11]1[CH2:12][CH2:13][N:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[C:9]([CH3:30])([CH3:29])[CH2:10]1)=[O:15]

Participants

4

Reactant 1

HCID 24738061HCID 24738061, compound

Product 1

HCID 69065309HCID 69065309, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl (1S,2S)-2-(4-(4-chlorophenyl)-3,3-dimethylpiperazine-1-carbonyl)cyclopentylcarbamate was dissolved in 4N HCl in dioxane to provide, after concentrating and drying, ((1R,2S)-2-aminocyclopentyl)(4-(4-chlorophenyl)-3,3-dimethylpiperazin-1-yl)methanone hydrochloride.

Workup

  1. customto provide
  2. concentrationafter concentrating
  3. customdrying

Sources & evidence

ORD record
ord-743b45b3e22444b68d23d99955a75061
Source dataset
uspto-grants-2009_11
Patent number
US07615556B2

Reaction notes

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