4-Tert-Butylaniline → HCID 11577396, compound

HRID 1434721Notes

Reaction equation

HRID 1434721 reaction equation
Cl[C:2]1[C:3]([C:8]2[CH:19]=[CH:18][C:11]3[C:12](O)=[N:13][S:14](=[O:16])(=[O:15])[C:10]=3[CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[F:20][C:21]([S:24]([C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=1)(=[O:26])=[O:25])([F:23])[F:22].C(C1C=CC(N)=CC=1)(C)(C)C>>[F:20][C:21]([F:23])([F:22])[C:2]1[C:3]([C:8]2[CH:19]=[CH:18][C:11]3[C:12]([NH:33][C:30]4[CH:31]=[CH:32][C:27]([S:24]([C:21]([F:23])([F:22])[F:20])(=[O:25])=[O:26])=[CH:28][CH:29]=4)=[N:13][S:14](=[O:16])(=[O:15])[C:10]=3[CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 698614-Tert-ButylanilineHCID 1363154-Aminophenyl trifluoromethyl sulphoneHCID 178527199HCID 178527199, compound

Product 1

HCID 11577396HCID 11577396, compound

Procedure

The title compound was prepared using the procedure of Example 1C, substituting the product of Example 7B (0.1476 g, 0.450 mmol) for the product of Example 1B and substituting 4-aminophenyl trifluoromethyl sulphone (0.2571 g, 1.14 mmol) for 4-tert-butylaniline. MS (ESI+) m/z 536 (M+H)+, m/z 534 (M−H)−; 1H NMR (CD3OD) δ 7.73 (dd, J 4.7, 8.1, 1H), 7.99 (d, J 8.2, 1H), 8.12 (s, 1H), 8.19 (d, J 9.2, 2H), 8.38 (m, 3H), 8.46 (d, J 7.8, 1H), 8.92 (d, J 4.4, 1H).

Sources & evidence

ORD record
ord-6fbdea3710424d3a90456974509fe2ca
Source dataset
uspto-grants-2009_11
Patent number
US07615570B2

Reaction notes

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