4-Tert-Butylaniline → HCID 11504050, compound

HRID 1434723Notes

Reaction equation

Cl[C:2]1[C:3]([C:8]2[CH:19]=[CH:18][C:11]3[C:12](O)=[N:13][S:14](=[O:16])(=[O:15])[C:10]=3[CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[F:20][C:21]([F:31])([F:30])[O:22][C:23]1[CH:29]=[CH:28][C:26]([NH2:27])=[CH:25][CH:24]=1.C(C1C=CC(N)=CC=1)(C)(C)C>>[F:20][C:21]([F:30])([F:31])[O:22][C:23]1[CH:29]=[CH:28][C:26]([NH:27][C:12]2[C:11]3[CH:18]=[CH:19][C:8]([C:3]4[C:2]([C:21]([F:31])([F:30])[F:20])=[CH:7][CH:6]=[CH:5][N:4]=4)=[CH:9][C:10]=3[S:14](=[O:16])(=[O:15])[N:13]=2)=[CH:25][CH:24]=1

Participants

Reactant 3

HCID 698614-Tert-Butylaniline

HCID 6008484-(Trifluoromethoxy)aniline

HCID 178527199HCID 178527199, compound

Product 1

HCID 11504050HCID 11504050, compound

Procedure

The title compound was prepared using the procedure as described in Example 1C, substituting the product of Example 7B for the product of Example 1B, and substituting 4-trifluoromethoxy aniline for 4-tert-butylaniline. MS (DCI+) m/z 488 (M+H)+ (50%), m/z 309 (M-177)+ (100%); 1H NMR (DMSO-d6) δ 7.53 (d, J 8.5, 2H), 7.78 (dd, J 5.1, 7.2, 1H), 8.01 (m, 3H), 8.15 (s, 1H), 8.42 (d, J 8.1, 1H), 8.57 (d, J 7.1, 1H), 8.99 (d, J 4.7, 1H), 11.11 (s, 1H).

Sources & evidence

ORD record: ord-4db5cd917dbe49cc9ae79944de08a10f
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615570B2

Reaction notes

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