4-Tert-Butylaniline → HCID 11677186, compound

HRID 1434726Notes

Reaction equation

HRID 1434726 reaction equation
Cl[C:2]1[C:3]([C:8]2[CH:19]=[CH:18][C:11]3[C:12](O)=[N:13][S:14](=[O:16])(=[O:15])[C:10]=3[CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][N:22]=1.C(C1C=CC(N)=CC=1)(C)(C)C>>[F:28][C:27]([F:30])([F:29])[C:2]1[C:3]([C:8]2[CH:19]=[CH:18][C:11]3[C:12]([NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27]([F:28])([F:30])[F:29])=[CH:23][N:22]=4)=[N:13][S:14](=[O:16])(=[O:15])[C:10]=3[CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 698614-Tert-ButylanilineHCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 178527199HCID 178527199, compound

Product 1

HCID 11677186HCID 11677186, compound

Procedure

The title compound was prepared using the procedure as described in Example 1C, substituting the product of Example 7B for the product of Example 1B, and substituting 2-amino-5-trifluoromethylpyridine for 4-tert-butylaniline. 1H NMR (300 MHz, CDCl3) δ 8.92 (d, 1H), 8.72 (d, 1H), 8.67 (s, 1H), 8.45 (brs, 1H), 8.15-8.19 (m, 2H), 8.11 (dd, 1H), 7.95 (d, 1H), 7.89 (d, 1H), 7.57 (dd, 1H). MS (m/z) 473.1.

Sources & evidence

ORD record
ord-1feb0d626cec4ceeb6bdb69c00972858
Source dataset
uspto-grants-2009_11
Patent number
US07615570B2

Reaction notes

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