3-[2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-(methylthio)benzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide → N-(5-Chloropyridin-2-yl)-3-[4-(methylthio)-2-(piperidin-4-yloxy)benzoylamino]pyridine-2-carboxamide

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Reaction Steps

The 3-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(methylthio)benzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide (184 mg, 0.31 mmol) was dissolved in TFA (4 mL). After 5 minutes, the reaction was concentrated in vacuo. The residue was diluted with dichloromethane (100 mL) and extracted with saturated aqueous sodium carbonate (2×10 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated to give the desired product as a white solid (139 mg, 0.28 mmol, 90%).

Provenance & Evidence