HRID1434849

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10655267

未命名化合物

结构：Cc1ccc(C(=S)Nc2cccnc2C(=O)Nc2ccc(Cl)cn2)c(O)c1

HCID136348818

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(C(=S)Nc2cccnc2C(=O)Nc2ccc(Cl)cn2)c(OC[C@H](C)CNC(=O)OC(C)(C)C)c1

HCID86620006

未命名化合物

收率 81%

PROCEDURE

实验过程

Using a procedure analogous to Example 38-D, N-(5-chloropyridin-2-yl)-3-[2-hydroxy-4-methylthiobenzoyl-amino]pyridine-2-carboxamide and (2R)-3-(t-butoxycarbonyl-amino)-2-methylpropanol gave the desired product as a solid (850 mg, 81%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dedd91480a4d40898cec950226e9b991
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07615568B2
来源说明: uspto-grants-2009_11

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18](=[S:27])[C:19]3[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:20]=3[OH:26])=[CH:15][CH:14]=[CH:13][N:12]=2)=[O:10])=[N:6][CH:7]=1.[C:28]([O:32][C:33]([NH:35][CH2:36][C@@H:37]([CH3:40])[CH2:38]O)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([NH:35][CH2:36][C@@H:37]([CH3:40])[CH2:38][O:26][C:20]1[CH:21]=[C:22]([CH3:25])[CH:23]=[CH:24][C:19]=1[C:18]([NH:17][C:16]1[C:11]([C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=2)=[O:10])=[N:12][CH:13]=[CH:14][CH:15]=1)=[S:27])=[O:34])([CH3:31])([CH3:30])[CH3:29]