HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-((2R)-3-hydroxy-2-methylpropyl)carbamate → 3-[2-[(2R)-3-(t-Butoxycarbonylamino)-2-methylpropoxy]-4-methylthiobenzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-((2R)-3-hydroxy-2-methylpropyl)carbamate | HCID 10655267 | — |
| Reactant | N-(5-chloropyridin-2-yl)-3-[2-hydroxy-4-methylthiobenzoylamino]pyridine-2-carboxamide | HCID 136348818 | — |
| Product | 3-[2-[(2R)-3-(t-Butoxycarbonylamino)-2-methylpropoxy]-4-methylthiobenzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide | HCID 86620006 | 81% |
Reaction Steps
Using a procedure analogous to Example 38-D, N-(5-chloropyridin-2-yl)-3-[2-hydroxy-4-methylthiobenzoyl-amino]pyridine-2-carboxamide and (2R)-3-(t-butoxycarbonyl-amino)-2-methylpropanol gave the desired product as a solid (850 mg, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615568B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-dedd91480a4d40898cec950226e9b991 |
| Source note | uspto-grants-2009_11 |