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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434854Generated: November 2, 2026

Potassium Carbonate → tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate

https://huagongshe.com/reaction/1434854

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
ReactantPiperidin-3-ylmethanolHCID 107308—
SolventAcetoneHCID 180—
Producttert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylateHCID 276385188%

Reaction Steps

Using a procedure analogous to Example 1-C (K2CO3, acetone), 3-hydroxymethylpiperidine gave the title compound as a solid (34.2 g, 88%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07615568B2
Source datasetuspto-grants-2009_11
ORD IDord-56293991414741669e972c77eaff9b78
Source noteuspto-grants-2009_11