Potassium Carbonate → tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate

HRID 1434854Notes

Reaction equation

HRID 1434854 reaction equation

[C:1]([O-:4])([O-])=[O:2].[K+].[K+].[OH:7][CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]1>CC(C)=O>[C:9]([O:4][C:1]([N:11]1[CH2:12][CH2:13][CH2:14][CH:9]([CH2:8][OH:7])[CH2:10]1)=[O:2])([CH3:14])([CH3:10])[CH3:8]

Participants

4

Reactant 2

HCID 11430Potassium Carbonate

HCID 107308Piperidin-3-ylmethanol

Product 1

HCID 2763851tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylateYield 88%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Using a procedure analogous to Example 1-C (K2CO3, acetone), 3-hydroxymethylpiperidine gave the title compound as a solid (34.2 g, 88%).

Sources & evidence

ORD record: ord-56293991414741669e972c77eaff9b78
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615568B2

Reaction notes

Loading…