Potassium Carbonate → 1-Boc-Azetidine-3-carboxylic acid

HRID 1434864Notes

Reaction equation

HRID 1434864 reaction equation

[C:1]([O-:4])([O-:3])=O.[K+].[K+].[NH:7]1[CH2:10][CH:9]([C:11]([OH:13])=[O:12])[CH2:8]1>CC(C)=O>[C:9]([O:3][C:1]([N:7]1[CH2:10][CH:9]([C:11]([OH:13])=[O:12])[CH2:8]1)=[O:4])([CH3:11])([CH3:10])[CH3:8]

Participants

4

Reactant 2

HCID 11430Potassium Carbonate

HCID 931923-azetidinecarboxylic Acid

Product 1

HCID 27559811-Boc-Azetidine-3-carboxylic acidYield 91%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Using a procedure analogous to Example 1-C (K2CO3, acetone), azetidine-3-carboxylic acid gave the title compound as a solid (3.61 g, 91%).

Sources & evidence

ORD record: ord-08b74336cd24458cb454f3e465b69112
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615568B2

Reaction notes

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