反应详情

To a solution of methyl 4-fluoro-2-(methoxymethoxy)-benzoate (10.6 g, 50 mmol) and DMSO (20 mL), under nitrogen, was added sodium ethanethiolate (5.8 g, 55 mmol) in portions. The exothermic reaction was stirred for 19 h, diluted with water, and extracted with ethyl acetate. The organic layer was concentrated; and the residue was dissolved in ether, filtered through diatomaceus earth, and concentrated to give intermediate methyl 4-(ethylthio)-2-(methoxymethoxy)benzoate.

1. customThe exothermic reaction
2. extractionextracted with ethyl acetate
3. concentrationThe organic layer was concentrated
4. dissolutionand the residue was dissolved in ether
5. filtrationfiltered through diatomaceus earth
6. concentrationconcentrated