Hydrochloric Acid → HCID 178473423, 화합물

HRID 1434888노트

반응식

HRID 1434888 반응식
Cl.[NH2:2][C:3]1[C:8]([NH2:9])=[C:7]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH:6]=[C:5]([NH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:4]=1.[CH2:21](OC(O)O)C>>[S:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:7]1[CH:6]=[C:5]([NH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:4]=[C:3]2[NH:2][CH:21]=[N:9][C:8]=12

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 5231668OrthoameisensaureathylesterHCID 57936800HCID 57936800, 화합물

생성물 1

HCID 178473423HCID 178473423, 화합물수율 91%

실험 절차

Hydrochloric acid (35 wt %, 892 μl) was added to 2,3-diamino-4-(2-thienyl)-6-ethoxycarbonylaminopyridine (1.28 g, 4.61 mmol) and orthoformic acid ethyl ester (24.6 ml), followed by stirring at room temperature for 3 days. This solution was filtered and the product was washed with ether to give 7-(2-thienyl)-5-ethoxycarbonylamino-3H-imidazo[4,5-b]pyridine (1.36 g, yield 91%).

후처리

  1. filtrationThis solution was filtered
  2. washthe product was washed with ether

출처 및 근거

ORD 기록
ord-0530d88a7e674fcb910d1801ef51a44c
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615628B2

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