Cyanamide → HCID 178508317, compound

HRID 1434891Notes

Reaction equation

HRID 1434891 reaction equation
O=[N:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.[N:14]#[C:15][NH2:16]>>[NH2:16][C:15]1[NH:2][CH:3]=[C:4]([C:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][CH:6]=2)[N:14]=1

Participants

3

Reactant 2

HCID 9864CyanamideHCID 22598433HCID 22598433, compound

Product 1

HCID 178508317HCID 178508317, compound

Procedure

In another embodiment of the invention, a method of synthesizing N,N-didesmethylgrossularine-1 2 is described comprising: condensing oxotryptamine 3 and cyanamide in the absence of air to produce 2-amino-4-(3-indolyl)imidazole 6; exposing 2-amino-4-(3-indolyl)imidazole 6 to an ammonia saturated methanol solution in air to produce imine 10; and exposing imine 10 to hydrolosis conditions to produce N,N-didesmethylgrossularine-1 2.

Workup

  1. customIn another embodiment of the invention, a method of synthesizing N,N-didesmethylgrossularine-1 2

Sources & evidence

ORD record
ord-18e3109b0f7e4930bc8799c529644e17
Source dataset
uspto-grants-2009_11
Patent number
US07615638B2

Reaction notes

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