4-Amino-2,2,6,6-tetramethylpiperidine → HCID 11166374, compound

HRID 1434911Notes

Reaction equation

HRID 1434911 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[S:15][C:14]([CH2:16][CH2:17][C:18]([CH3:21])([OH:20])[CH3:19])=[CH:13][CH:12]=2)[C:8]([O:22][CH3:23])=[CH:7][N:6]=1)(=O)=O.[CH3:24][C:25]1([CH3:34])[CH2:30][CH:29]([NH2:31])[CH2:28][C:27]([CH3:33])([CH3:32])[NH:26]1.CCN(C(C)C)C(C)C>CO>[CH3:23][O:22][C:8]1[C:9]([C:11]2[S:15][C:14]([CH2:16][CH2:17][C:18]([CH3:21])([OH:20])[CH3:19])=[CH:13][CH:12]=2)=[N:10][C:5]([NH:31][CH:29]2[CH2:30][C:25]([CH3:34])([CH3:24])[NH:26][C:27]([CH3:33])([CH3:32])[CH2:28]2)=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 375244-Amino-2,2,6,6-tetramethylpiperidineHCID 81531DiisopropylethylamineHCID 57936287HCID 57936287, compound

Product 1

HCID 11166374HCID 11166374, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
120 °C

Procedure

4-[5-(2-Methanesulfonyl-5-methoxy-pyrimidin-4-yl)-thiophen-2-yl]-2-methyl-butan-2-ol (240 mg, 0.673 mmol) was mixed with 2,2,6,6-Tetramethyl-piperidin-4-ylamine (0.5 ml, 2.86 mmol) and DIEA (0.5 ml, 2.92 mmol) and heated to 120° C. in a closed flask for 2 hours. The residue was then diluted with MeOH and purified by preparative HPLC to give the title compound. Yield: 8 mg (3%).

Workup

  1. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-ceeae9b8524a4aa6af1df2cd3c8a8c77
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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