m-Chloroperbenzoic acid → 4-(5-Bromo-thiophen-2-yl)-2-methanesulfinyl-pyrimidine

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Reaction Steps

4-(5-Bromo-thiophen-2-yl)-2-methylsulfanyl-pyrimidine (144 mg, 0.5 mmol) was dissolved in DCM (5 ml) and treated at 0° C. with mCPBA (content 70%, 112 mg, 0.65 mmol) for 15 minutes. The reaction mixture was washed with 2N-solution of sodium carbonate, the organic phase dried over sodium sulfate, filtered and evaporated to dryness and purified via chromatography on silicagel (acetone/hexanes:20/80 to 40/60) to give the title compound as white crystals. Yield: 120 mg (80%).

Provenance & Evidence