反应详情

4-(5-Bromo-thiophen-2-yl)-2-methylsulfanyl-pyrimidine (144 mg, 0.5 mmol) was dissolved in DCM (5 ml) and treated at 0° C. with mCPBA (content 70%, 112 mg, 0.65 mmol) for 15 minutes. The reaction mixture was washed with 2N-solution of sodium carbonate, the organic phase dried over sodium sulfate, filtered and evaporated to dryness and purified via chromatography on silicagel (acetone/hexanes:20/80 to 40/60) to give the title compound as white crystals. Yield: 120 mg (80%).

1. washThe reaction mixture was washed with 2N-solution of sodium carbonate
2. dry with materialthe organic phase dried over sodium sulfate
3. filtrationfiltered
4. customevaporated to dryness
5. custompurified via chromatography on silicagel (acetone/hexanes:20/80 to 40/60)