HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-2,2,6,6-tetramethylpiperidine → {4-[5-Bromothiophen-2-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-2,2,6,6-tetramethylpiperidine | HCID 37524 | — |
| Reactant | 4-(5-Bromo-thiophen-2-yl)-2-methanesulfinyl-pyrimidine | HCID 57936157 | — |
| Product | {4-[5-Bromothiophen-2-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine | HCID 57936128 | — |
Reaction Steps
4-(5-Bromo-thiophen-2-yl)-2-methanesulfinyl-pyrimidine (110 mg, 0.36 mmol) and 4-amino-2,2,6,6,-tetramethyl piperidine (0.6 ml) were heated to 130° C. for 45 minutes. Evaporation and chromatography on silicagel (TBDME/MeOH/ammonia:90/9/1) gave the title compound as slightly coloured crystals. Yield: 100 mg (70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615562B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-f999ee9fae2e4d2fa3461844f1b1f305 |
| Source note | uspto-grants-2009_11 |