(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine → HCID 11430421, compound

HRID 1434938Notes

Reaction equation

HRID 1434938 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:3]=1.[CH3:19][O:20][C:21]1[CH:25]=[CH:24][S:23][C:22]=1[CH2:26][CH2:27][C:28]([CH3:31])([OH:30])[CH3:29]>>[CH3:19][O:20][C:21]1[CH:25]=[C:24]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]3[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]3)[N:3]=2)[S:23][C:22]=1[CH2:26][CH2:27][C:28]([CH3:31])([OH:30])[CH3:29]

Participants

3

Reactant 2

HCID 57936167(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amineHCID 69068728HCID 69068728, compound

Product 1

HCID 11430421HCID 11430421, compound

Procedure

The title compound was prepared analogous to Method C, starting from (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and 4-(3-methoxy-thiophen-2-yl)-2-methyl-butan-2-ol (prepared by Pd/C hydrogenation of (E)-3-(3-Methoxy-thiophen-2-yl)-acrylic acid methyl ester, followed by reaction with MeMgBr (Step A of Method A)).

Sources & evidence

ORD record
ord-36f0c9e4abd44bef82093604e08f1442
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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