(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine → {4-[5-(2-Methoxy-ethoxy)-thiophen-2-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

HRID 1434944Notes

Reaction equation

HRID 1434944 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:3]=1.[CH3:19][O:20][CH2:21][CH2:22][O:23][C:24]1[S:25][CH:26]=[CH:27][CH:28]=1>>[CH3:19][O:20][CH2:21][CH2:22][O:23][C:24]1[S:25][C:26]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]3[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]3)[N:3]=2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 57936167(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amineHCID 666317542-(2-Methoxy-ethoxy)-thiophene

Product 1

HCID 11165223{4-[5-(2-Methoxy-ethoxy)-thiophen-2-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Procedure

The title compound was prepared analogous to Method C, starting from (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and 2-(2-methoxy-ethoxy)-thiophene (prepared by cupric oxide-mediated coupling of 2-methoxy-ethanol and 2-iodo-thiophene, J. Am. Chem. Soc. 1953, 3697).

Sources & evidence

ORD record
ord-9f0b643975684a2f95d4c56fe811b0dd
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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