HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine → {4-[5-(2-Methoxy-ethoxy)-thiophen-2-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine | HCID 57936167 | — |
| Reactant | 2-(2-Methoxy-ethoxy)-thiophene | HCID 66631754 | — |
| Product | {4-[5-(2-Methoxy-ethoxy)-thiophen-2-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine | HCID 11165223 | — |
Reaction Steps
The title compound was prepared analogous to Method C, starting from (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and 2-(2-methoxy-ethoxy)-thiophene (prepared by cupric oxide-mediated coupling of 2-methoxy-ethanol and 2-iodo-thiophene, J. Am. Chem. Soc. 1953, 3697).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615562B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-9f0b643975684a2f95d4c56fe811b0dd |
| Source note | uspto-grants-2009_11 |